Evaluation, diagnosis, and treatment of children and adolescents with complex multiple psychiatric comorbidities and out-of-control behaviors is a daunting task. The clinical challenge of engaging seriously emotionally-disturbed (SED) youth and family members in intensive treatment appears to have stimulated a proliferation of flexible, relatively unstructured, publicly funded, home-based interventions that embrace system-of-care values. Unfortunately, these home-based services typically do not employ such structures as a treatment manual, model specific training, and active supervision by psychiatrists, nor do they collect ongoing fidelity and outcome data. This Workshop, illustrated with video vignettes, presents an ecologically-based, comprehensive model of in-home treatment that shows robust, data-supported evidence of clinical effectiveness. Participants learn the manualized evaluation and treatment approach utilized by the Intensive, In-home, Child and Adolescent Psychiatric Service.