Cannabis is the primary substance of abuse in adolescents, who make up the greatest proportion of patients receiving treatment for cannabis use disorders (CUDs). The risk of developing a CUD is greatest between ages 15-20, with adolescents being more vulnerable to developing dependence than adults, even when low levels of use are reported. In addition to its impact on adolescent development, early cannabis use has been shown to predict future drug use patterns or onset of other substance use disorders. Additionally, its relationship as a co-occurring disorder alongside depression, anxiety, and psychosis has been described, leading to worsening treatment outcomes. This Workshop begins with a brief presentation on the epidemiology and neurobiology of CUDs in adolescents. Subsequently, through interactive case presentations, participants build a skill set on how to diagnose and treat adolescents with CUDs. Topics include overcoming barriers to reporting honest drug-use, screening for use and its consequences, diagnosing abuse or dependence, getting