This Workshop demonstrates how certain neuropsychiatric manifestations of inflammatory bowel disease (IBD), e.g., depression, sleep disturbance, and abdominal pain, are assessed and treated in a research study and then how the resulting personalized interventions are translated into clinical health care delivery. Three stages of this process are defined. Stage 1: Assessment of symptoms and modifying an existing cognitive behavioral therapy (CBT) paradigm to develop a treatment to be tested. Stage 2: Assessment and characterization of symptoms and testing of CBT modified to treat sleep disturbances in youth with IBD. Stage 3: Identification of both inflammatory and non-inflammatory endo-phenotypes of depression in youth with IBD and translating efficacy findings from a randomized clinical trial of CBT targeting these depressive subtypes.